Phytochemicals reverse P-glycoprotein mediated multidrug resistance via signal transduction pathways

HZ08 Reverse P-Glycoprotein Mediated Multidrug Resistance In Vitro and In Vivo

BACKGROUND Multidrug efflux transporter P-glycoprotein (P-gp) is highly expressed on membrane of tumor cells and is implicated in resistance to tumor chemotherapy. HZ08 is synthesized and studied in order to find a novel P-gp inhibitor. METHODS MDCK-MDR1 monolayer transport, calcein-AM P-gp inhibition and P-gp ATPase assays were used to confirm the P-gp inhibition capability of HZ08. Furtherm...

Bromocriptine reverses P-glycoprotein-mediated multidrug resistance in tumor cells.

One of the most important causes of anticancer treatment failure is the development of multidrug resistance (MDR). The main characteristics of tumor cells displaying the MDR phenomena are cross-resistance to structurally unrelated cytotoxic drugs having different mechanisms of action and the overexpression of the MDR1 gene, which encodes a transmembrane glycoprotein named P-glycoprotein (P-gp)....

Inhibition of P-glycoprotein mediated multidrug resistance by stemofoline derivatives.

Resistance to chemotherapy in cancer patients has been correlated to the overexpression of the ATP-binding cassette (ABC) drug transporters including P-glycoprotein (P-gp) that actively efflux chemotherapeutic drugs from cancer cells. We examined the multidrug resistance reversing property of stemofoline derivatives in drug-resistance human cervical carcinoma (KB-V1) and human leukemic (K562/Ad...

Multidrug Resistance Protein (P-Glycoprotein; MDR1)

Multivariate Analysis and Reverse Engineering of Signal Transduction Pathways

This thesis presents mathematical and computational approaches to studying signal transduction pathways. The biology of cellular signalling is introduced, highlighting the importance of signalling pathways in regulating the processes of cell division and proliferation. A brief history of mathematical approaches to such systems is presented. Two multivariate analysis methods, principal component...